Joel McHale sebagai Elliot, Boog's best friend and the main protagonist. He was supposed to marry Giselle, but abandoned her due to new emotions.
Mike Epps sebagai Boog, the deuteragonist. He leads the rescue mission to save Mr. Weenie.
Cody Cameron sebagai Mr. Weenie, a German wiener dog. He was captured by the pets and the forest animals leave the forest to save him. He is the deuteragonist of the film.
Jane Krakowski sebagai Giselle, Elliot's fiance who is scared of getting married.
Billy Connolly sebagai McSquizzy, a squirrel who joins the forest animals in the rescue mission for Mr. Weenie.
Crispin Glover sebagai Fifi, a toy poodle and the main antagonist. He has a deep hatred over wild animals and slowly begins to lose his sanity.
Danny Mann sebagai Serge, a duck who joins the forest animals in their rescue mission for Mr. Weenie along with his companion Deni.
